So is there a catch? The answer is yes and no. The X6800, as stated, is unlocked up and down, allowing the flexibility to do anything you wish with the outstanding head room of the Core 2 Duo architecture. The rest of the Core 2 Duo chips are hard-locked up and down, which greatly limits the flexibility of the head room which often runs 1000MHz, 1500 MHz, or more - depending on the CPU and motherboard. You could only access this extra power at the stock multiplier. This is actually a big negative compared to AM2 processors, where all chips are at least unlocked down.
Source:ASUS P5B: New BIOS Adds Unlocking & Improved Overclocking